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In the novel Death Comes as the End, Mersu is a priest and physician. After Yahmose and Sobek had been poisoned by drinking some wine, Imhotep sent for him. By treating them with emetics, herbs and incantations, he was able to save Yahmose who only sipped at his wine but Sobek had swallowed too much and died. Later, Mersu helped Imhotep draft a petition prayer to Ashayet, the late wife of Imhotep, asking for her protection on his family.

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