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In the novel The Sittaford Mystery, Dr Warren is a doctor in Exhampton. When Major Burnaby approached Constable Graves because he could not get Captain Trevelyan to answer the door, Graves decided to go over to Trevelyan's house to take a look. On the way, he fetched Dr Warren who lived near the police station. Together the three of them got into the house through an open window and discovered the body of the murdered captain.

Warren was able to quickly identify the murder weapon: a green baize tube filled with sand which Trevelyan used as a draught excluder. Warren also estimated the time of death as any time from two to three hours before. Since they examined the body at about eight in the evening, this would place the time of death as some time between six and five o'clock. This uncannily agreed with the seance Burnaby had attended at Sittaford House which predicted that Trevelyan had died at five twenty-five.

Later, when meeting Emily Trefusis, Warren agreed that the time of death could be stretched to about four o'clock.

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